期刊
CARBOHYDRATE RESEARCH
卷 389, 期 -, 页码 46-49出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2013.12.025
关键词
Trehalase; Enzyme inhibitors; Trehalose; Iminosugars; Deoxynojirimycin
资金
- University of Milano-Bicocca FAR
- MIUR [PRIN2008/24M2HX]
A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and alpha-amylase from human saliva. All the tested compounds (2-4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity toward the insect glycosidase. No activity was observed against alpha-amylase. (C) 2014 Elsevier Ltd. All rights reserved.
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