期刊
CARBOHYDRATE RESEARCH
卷 356, 期 -, 页码 110-114出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2011.10.039
关键词
Iminosugar; Glycosidase; Inhibitor; Azepane
Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.
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