期刊
CARBOHYDRATE RESEARCH
卷 346, 期 15, 页码 2445-2450出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2011.08.002
关键词
Chitosan; N,N,N-Trimethyl chitosan; Quaternary ammonium chitosan; Antibacterial activity
资金
- National Natural Science Foundation of China [20574024]
- Provincial Natural Science Foundation of Fujian [E0810019, 2009J01029, 2011J01312]
- Key Projection of Science and Technology of Fujian Province [2009H0030]
N,N,N-Trimethyl O-(2-hydroxy-3-trimethylammonium propyl) chitosans (TMHTMAPC) with different degrees of O-substitution were synthesized by reacting O-methyl-free N,N,N-trimethyl chitosan (TMC) with 3-chloro-2-hydroxy-propyl trimethyl ammonium chloride (CHPTMAC). The products were characterized by H-1 NMR, FTIR and TGA, and investigated for antibacterial activity against Staphylococcus aureus and Escherichia coli under weakly acidic (pH 5.5) and weakly basic (pH 7.2) conditions. TMHTMAPC exhibited enhanced antibacterial activity compared with TMC, and the activity of TMHTMAPC increased with an increase in the degree of substitution. Divalent cations (Ba2+ and Ca2+) strongly reduced the antibacterial activity of chitosan, O-carboxymethyl chitosan and N,N,N-trimethyl-O-carboxymethyl chitosan, but the repression on the antibacterial activity of TMC and TMHTMAPC was weaker. This indicates that the free amino group on chitosan backbone is the main functional group interacting with divalent cations. The existence of 100 mM Na+ slightly reduced the antibacterial activity of both chitosan and its derivatives. (C) 2011 Elsevier Ltd. All rights reserved.
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