期刊
CARBOHYDRATE RESEARCH
卷 346, 期 13, 页码 1827-1836出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2011.06.021
关键词
Heparin; Heparinoid disaccharides; D-Glucuronic acid; L-Iduronic acid; Sulfonatomethyl analogues
资金
- TAMOP [4.2.1/B-09/1/KONV-2010-0007]
- European Union
- European Social Fund
- Hungarian Research Fund [K 62802]
D-Glucuronate and L-iduronate-containing disaccharides related to the antithrombin-binding domain of heparin were prepared. The carboxylic function of the uronic acid unit was formed on a disaccharide level in the case of the glucuronate, while on a monosaccharide level in the case of the iduronate derivatives. Synthesis of their sulfonic acid analogues was carried out analoguosly applying sulfonatomethyl-containing acceptors in the form of either salts or methyl esters. Significant difference could be observed in the methyl ether formation reactions of the sulfonatomethyl-containing uronate disaccharides and the non-sulfonic acid uronates. (C) 2011 Elsevier Ltd. All rights reserved.
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