期刊
CARBOHYDRATE RESEARCH
卷 346, 期 1, 页码 16-25出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.10.017
关键词
Click chemistry; CuAAC; Glycosyl triazoles; alpha-Glucosidase; Glucose-6-phosphatase; Glycogen phosphorylase
资金
- CSIR New Delhi
- DRDO New Delhi
An efficient synthesis of novel 1,2,3-1H-triazolyl glycohybrids with two or more than two sugar units or a chromenone moiety via copper-catalysed azide-alkyne cycloaddition (CuAAC), a 1,3-dipolar cycloaddition of glycosyl azides to 2,3-unsaturated alkynyl glycosides or propargyloxy coumarins is described. The synthesised glycohybrids were screened for their a-glucosidase, glycogen phosphorylase and glucose-6-phosphatase inhibitory activities. A few of the glycohybrids showed promising inhibitory activities against these enzymes. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据