Studies on a new marine streptomycete BT-408 producing polyketide antibiotic SBR-22 effective against methicillin resistant Staphylococcus aureus

22 and showing antibacterial activity against methicillin resistant Staphylococcus aureus has been characterized and found to be a novel. strain of Streptomyces psammoticus. Nutritional and cultural conditions for the production of antibiotic by this organism under shake-flask conditions have been optimized. Glucose and ammonium nitrate were found to be best carbon and nitrogen sources respectively for growth and antibiotic production. Similarly initial medium pH of 7.2, incubation temperature of 30° C and incubation time of 96h were found to be optimal. Optimization of medium and cultural conditions resutted in 1.82-fold increase in antibiotic yield. © 2004 Elsevier GmbH. All. rights reserved.