期刊
CANCER AND METASTASIS REVIEWS
卷 24, 期 1, 页码 95-105出版社
SPRINGER
DOI: 10.1007/s10555-005-5050-6
关键词
head and neck cancer; the immune system; vaccination therapies; tumor escape; immune suppression
类别
资金
- NIDCR NIH HHS [R01-DE13918, P01-DE12321] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [P01DE012321, R01DE013918] Funding Source: NIH RePORTER
The development of head and neckcancer (HNC) is strongly influenced by the host immune system. Recent evidence for the presence of functional defects and for apoptosis of tumor-infiltrating as well as circulating T cells in patients with HNC emphasizes the fact that their antitumor responses are compromised. It appears that H&N tumors not only effectively escape from the host immune system but also actively corrupt the host antitumor response via several distinct mechanisms. Strategies for restoring immune competence of patients with HNC and for preventing tumor escape are necessary for more effective control of tumor progression. New immunotherapeutic approaches include cytokine-based and DC-based vaccines which are aimed at the restoration of tumor-specific responses and at the protection of immune cells from tumor-induced apoptosis.
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