期刊
MOLECULAR DIVERSITY
卷 9, 期 1-3, 页码 171-186出版社
SPRINGER
DOI: 10.1007/s11030-005-1314-x
关键词
cheminformatics; cyclases; cyclopeptides; macrocycles; natural products; polyketides; terpenoids
类别
资金
- Deutsche Forschungsgemeinschaft [CERC3, GRK 894]
- European Union (Combiocat)
Macrocyclic natural products often display remarkable biological activities, and many of these compounds (or their derivatives) are used as drugs. The chemical diversity of these compounds is immense and may provide inspiration for innovative drug design. Therefore, a database of naturally occurring macrocycles was analyzed for ring size, molecular weight distribution, and the frequency of some common substructural motifs. The underlying principles of the chemical diversity are reviewed in terms of biosynthetic origin and nature's strategies for diversity and complexity generation in relation to the structural diversity and similarities found in the macrocycle database. Finally, it is suggested that synthetic chemists should use not only nature's molecules, but also nature's strategies as a source of inspiration. To illustrate this, the biosynthesis of macrocycles by non-ribosomal peptide synthetases and terpene and polyketide cyclases, as well as recent advances of these strategies in an integrated synthesis/biotechnology approach are briefly reviewed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据