期刊
CARBOHYDRATE RESEARCH
卷 345, 期 11, 页码 1541-1547出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.05.004
关键词
PSGL-1; Core-2 glycan; Glycopeptides; Solid-phase synthesis
资金
- National Institutes of Health
- Juvenile Diabetes Research Foundation
Selectins (L, E, and P) are vascular endothelial molecules that play an important role in the recruitment of leukocytes to inflamed tissue. In this regard, P-Selectin glycoprotein-1 (PSGL-1) has been identified as a ligand for P-Selectin. PSGL-1 binds to P-Selectin through the interaction of core-2 O-glycan expressing sialyl Lewis' oligosaccharide and the three tyrosine sulfate residues. Herein, we report the synthesis of threonine-linked core-2 O-glycan as an amino acid building block for the synthesis of PSGL-1. This building block was further incorporated in the Fmoc-assisted solid-phase peptide synthesis to provide a portion of the PSGL-1 glycopeptide. (C) 2010 Elsevier Ltd. All rights reserved.
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