期刊
CARBOHYDRATE RESEARCH
卷 345, 期 12, 页码 1774-1780出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.06.002
关键词
Chitosan; gamma-PGA; Polyelectrolyte complex (PEC); Antibacterial ability; Biocompatibility
资金
- National Science Council, Republic of China (NSC) [95R0201]
In this study, we prepared a polyelectrolyte complex (PEC) hydrogel comprising chitosan as the cationic polyelectrolyte and gamma-poly(glutamic acid) (gamma-PGA) as the anionic polyelectrolyte. Fourier transform infrared spectroscopy revealed that ionic complex interactions existed in the chitosan-gamma-PGA PEC hydrogels. The compressive modulus increased upon increasing the degree of complex formation in the chitosan-gamma-PGA PEC hydrogel; the water uptake decreased upon increasing the degree of complex formation. At the same degree of complex formation, the compressive modulus was larger for the chitosan-dominated PEC hydrogels; the water uptake was larger for the gamma-PGA-dominated ones. Scanning electron microscopy images revealed the existence of interconnected porous structures (pore size: 30-100 mu m) in all of the chitosan-gamma-PGA PEC hydrogels. The chitosan-gamma-PGA PEC hydrogels also exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus. In addition, in vitro cell culturing of 3T3 fibroblasts revealed that all the chitosan-gamma-PGA PEC hydrogels were effective in promoting cell proliferation, especially the positively charged ones (chitosan-dominated). Therefore, the chitosan-gamma-PGA polyelectrolyte hydrogel appears to have potential as a new material for biomedical applications. (C) 2010 Elsevier Ltd. All rights reserved.
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