期刊
CARBOHYDRATE RESEARCH
卷 345, 期 9, 页码 1225-1229出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.04.003
关键词
Sialic acid; N-Glycolylneuraminic acid; Antigen
资金
- Cancer Research Institute/Samuel and Ruth Engelberg Fellowship
- NIH [R01GM32373]
N-Glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid, which may play a significant role in human pathologies, such as cancer and vascular disease. Further studies into the role of Neu5Gc in human disease are hindered by limited sources of this carbohydrate. Using a chemo-enzymatic approach, Neu5Gc was accessed in six steps from glucose. The synthesis allows access to gram-scale quantities quickly and economically and produces Neu5Gc in superior quality to commercial sources. Finally, we demonstrate that the synthesized Neu5Gc can be incorporated into the cell glycocalyx of human cells, which do not naturally synthesize this sugar. The synthesis produces Neu5Gc suitable for in vitro or in vivo use. (C) 2010 Elsevier Ltd. All rights reserved.
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