期刊
CARBOHYDRATE RESEARCH
卷 345, 期 5, 页码 607-620出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.01.002
关键词
Ursolic acid; Oleanolic acid; Saponin; N-Acetylglucosamine; Cytotoxic activity
资金
- National Natural Science Foundation of China [30701046]
Fourteen ursolic acid and oleanolic acid saponins with N-acetyl-beta-D-glucosamine, and (1 -> 4)-linked and (1 6)-linked N-acetyl-beta-D-glucosamine oligosaccharide residues were synthesized in a convergent manner. The structures of all compounds were confirmed by (1)H NMR and (13)C NMR spectroscopy and by mass spectrometry, and their cytotoxic activities were assayed in three cancer cell lines. Only oleanolic acid-3-yl beta-D-GluNAc showed significant cytotoxicity against HL-60 and BGC-823. (C) 2010 Published by Elsevier Ltd.
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