期刊
CARBOHYDRATE RESEARCH
卷 345, 期 8, 页码 1023-1027出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.03.005
关键词
Dendrobium nobile Lindl; Polysaccharide; Structure; Immunological activity
资金
- National Natural Science Foundation of China [20872024]
- Ministry of Education of China [109091]
- Outstanding Young Researchers in Higher Schools of Anhui Province of China [2009SQRZ016ZD]
- Scientific Research Foundation
A water-soluble polysaccharide DNP-W2 composed of glucose. mannose. and galactose in the molar ratio of 6.1:2.9.2 0 had been isolated from the stems of Dendrobium nobile Its molecular weight was 1 8 x 10(4) Da determined by HPGPC Structural features of DNP-W2 were investigated by a combination of chemical and instrumental analysis. including FTIR, GC, GC-MS, periodate oxidation-Smith degradation, methylation analysis, partial acid hydrolysis, and NMR spectroscopy The results showed that DNP-W2 is a 2-O-acetylgalactomannoglucan and has a backbone consisting of (1 -> 4)-linked beta-D-Glcp, (1 6)-linked beta-D-Glcp, and (1 -> 4)-linked beta-D-Manp, with branches at O-6 of (1 -> 4)-linked beta-D-Glcp and beta-D-Manp The branches are composed of alpha-D-Galp The acetyl groups are substituted at O-2 of (1 -> 4)-linked Manp. Preliminary tests in vitro reveals that DNP-W2 can stimulate ConA- and LPS-incluced land B lymphocyte proliferation. (C) 2010 Elsevier Ltd All rights reserved.
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