期刊
CARBOHYDRATE RESEARCH
卷 345, 期 10, 页码 1291-1298出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.12.013
关键词
Sugar phosphoramidates; Enzyme inhibitors; PKB; Glycolipid analogues; Cyclitol analogues; Glucose
Glucose-based analogues of phosphatidylinositol 3-phosphate were straightforwardly synthesised from 2,3,4,6-tetra-O-acetyl-D-glucosyl bromide as protein kinase B (PKB/Akt) inhibitors. beta-D-Glucuronyl diethyl phosphoramidate was identified as a promising hit through biological screening in two different cellular systems. In addition, RNA interference experiments (siRNA) provide evidence of the ability of the compound to exert biological effects specifically through Akt signalling. (C) 2009 Elsevier Ltd. All rights reserved.
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