期刊
CARBOHYDRATE RESEARCH
卷 344, 期 18, 页码 2444-2453出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.09.007
关键词
(9 '-Anthracenyl)methylene acetal; Regioselective; Hydrogenolysis; High-temperature MD; DFT
资金
- Hungarian National Fund [NK48798, K62802]
Dioxane-type (9'-anthracenyl)methylene acetal of methyl 2,3-di-O-methyl-alpha-D-glucopyranoside was cleaved with LiAlH4/AlCl3 (3:1) or with Na(CN)BH3-HCl regioselectively to provide the 4- or 6-O-(9'-anthracenyl)methyl ether, respectively. Hydrogenolytic reaction of the exo and endo isomers of dioxolane-type acetals proved to be directed by the configuration of the acetalic carbon as well as by the intramolecular participation of the adjacent-free hydroxyl; ring-opening reaction of the endo isomer of the methyl 2,3-O-(9'-anthracenyl)methylene-alpha-L-rhamnopyranoside took place with complete selectivity resulting in the axial (9'-anthracenyl)methyl ether, whereas a 1:1 mixture of the axial and equatorial ethers was formed upon the same reaction of the exo isomer. Catalytic hydrogenation of the sugar acetals resulted in (9',10'-dihydro-9'-anthracenyl)methylene derivatives without affecting the acetalic center. High-temperature molecular dynamics simulations and DFT (Density Functional Theory) geometry optimizations were carried out to study the conformation of the dioxane-type (9',10'-dihydro-9'-anthracenyl)methylene acetal. (C) 2009 Elsevier Ltd. All rights reserved.
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