期刊
CARBOHYDRATE RESEARCH
卷 344, 期 6, 页码 747-752出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.02.003
关键词
Ganglioside; Sialic acid; N-Glycolylneuraminic acid; Glycosylation
资金
- Kanagawa University
- Japan Society for the Promotion of Science (JSPS) [20710171]
- Grants-in-Aid for Scientific Research [20710171] Funding Source: KAKEN
The first synthesis of the ganglioside LLG-3 tetrasaccharide, which has attractive biological activities as well as a unique structure, is described. A C8-methoxy decorated sialic acid building block was initially prepared and a glycolic acid moiety was then introduced by sialylation. Amide condensation between the sialyl glycolic acid and an amino group at C5 on the sialyllactoside unit afforded the fully protected LLG-3 tetrasaccharide. Finally, the desired tetrasaccharide part of LLG-3 was obtained after careful global deprotection. [GRAPHICS] (C) 2009 Elsevier Ltd. All rights reserved.
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