期刊
CARBOHYDRATE RESEARCH
卷 344, 期 5, 页码 613-626出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.01.018
关键词
C-Glycosyl compounds; beta-Amino acids; beta-Peptides; Glycopeptides
资金
- Ajinomoto Award in Synthetic Organic Chemistry, Japan
- Nara Women's University Intramural
- The Japan Science Society
Ten C-glycosyl beta(2)- and beta/beta(2)-peptides with three to eight amino acid residues have been prepared. Solution and solid-phase peptide syntheses were employed to assemble beta(2)-amino acids in which C-glycosylic substituents are attached to the C-2 position of beta-amino acids. Conformational analysis of the C-glycosyl beta(2)-peptides using NMR and CD spectra indicates that the tripeptide can form a helical secondary structure. Besides, helix directions of the C-glycosyl beta/beta(2)-peptides are governed by the configuration at the carbon of the peptide backbone that originates from the stereocenter of the C-glycosyl beta(2)-amino acids. (C) 2009 Elsevier Ltd. All rights reserved.
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