期刊
CARBOHYDRATE RESEARCH
卷 344, 期 3, 页码 291-297出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.11.015
关键词
Indoloquinoline alkaloid; Jusbetonin; PPA catalyzed cyclization; Glycosylation; Total synthesis
资金
- Key International Cooperation Project of CMST [2008DFA31040]
- National Basic Research Program Grant [2003CB716403]
Jusbetonin, an indolo[3,2-b]quinoline alkaloid glycoside originally isolated from Justicia betonica, and its derivatives were synthesized. The key steps in the synthetic strategy were the construction of indolo[3,2-b]quinoline skeleton and efficient coupling with the saccharides, in which the alpha-D-glycopyranosyl bromides were shown to be effective donors. Primary screening showed that all synthesized compounds possessed moderate proliferation inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved.
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