期刊
CARBOHYDRATE RESEARCH
卷 344, 期 16, 页码 2245-2249出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.08.014
关键词
Total synthesis; Flavonoid glycoside; PTC; Glycosylation
资金
- SIPI
- State Key Lab of Bioorganic and Natural Products (SIOC, CAS)
An efficient total synthesis of 7-O-beta-D-glucopyranosyl-4'-O-alpha-L-rhamnopyranosyl apigenin (1) was developed in only four steps from naringenin. Compared with our previously reported first total synthesis route (six steps and 19.6% overall yield), this new route contained two steps of highly regioselective glycosylation without any selective protection steps. 7,4'-di-O-beta-D-glucopyranosyl apigenin (2) was also prepared efficiently by this method. The method is environmentally friendly, economical, and provides a greener method for flavonoid synthesis starting from an inexpensive flavanone. (C) 2009 Elsevier Ltd. All rights reserved.
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