期刊
CARBOHYDRATE RESEARCH
卷 344, 期 6, 页码 762-770出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.02.013
关键词
Glycopeptide; Native chemical ligation; Haloacetamide method
资金
- Ministry of Education, Culture, Sports, Science, and Technology [17750170, 17GS0420]
- Grants-in-Aid for Scientific Research [17750170, 17GS0420] Funding Source: KAKEN
To prepare a small library of homogeneous glycoconjugates with varying oligosaccharide structures, a combinatorial strategy was employed. The target glycopeptide was divided into two peptide segments (A and B) and both were prepared by solid phase peptide synthesis. These peptides, which can be coupled by native chemical ligation through an amide bond, were subsequently Coupled to two kinds of human complex type oligosaccharides. This process systematically afforded the desired glycoconjugate library. (C) 2009 Elsevier Ltd. All rights reserved.
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