期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 67, 期 -, 页码 719-758出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.67.032003.154341
关键词
ion channels; epithelia; bestrophin; secretion; CFTR
类别
资金
- NEI NIH HHS [EY104852] Funding Source: Medline
- NIDCR NIH HHS [DE-09,692, DE13539] Funding Source: Medline
- NIGMS NIH HHS [GM60448] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [P01DE013539, R01DE009692] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060448] Funding Source: NIH RePORTER
Calcium-activated chloride channels (CaCCs) play important roles in cellular physiology, including epithelial secretion of electrolytes and water, sensory transduction, regulation of neuronal and cardiac excitability, and regulation of vascular tone. This review discusses the physiological roles of these channels, their mechanisms of regulation and activation, and the mechanisms of anion selectivity and conduction. Despite the fact that CaCCs are so broadly expressed in cells and play such important functions, understanding these channels has been limited by the absence of specific blockers and the fact that the molecular identities of CaCCs remains in question. Recent status of the pharmacology and molecular identification of CaCCs is evaluated.
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