期刊
CARBOHYDRATE RESEARCH
卷 343, 期 7, 页码 1153-1162出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.02.013
关键词
1,3-cycloaddition; glycosyl azide; sugar triazole; sodium ascorbate
5-Azido-5-deoxy-xylo-, ribo-, and arabinofuranoses were prepared by the reaction of the respective 5-O-(methanesulfonyl) or p-toluenesulfonyl derivatives with NaN3 in DMF. The intermediate 5-azido-5-deoxy glycofuranoses on 1,3-cycloaddition with different alkynes in the presence Of CUSO4 and sodium ascorbate gave the corresponding sugar triazoles in very good yields. The synthesized sugar triazoles were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv, where one of the compounds displayed mild antitubercular activity in vitro with MIC 12.5 mu g/mL. (c) 2008 Elsevier Ltd. All rights reserved.
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