期刊
CARBOHYDRATE RESEARCH
卷 343, 期 10-11, 页码 1718-1729出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.03.033
关键词
GPI anchor; CD52 antigen; CAMP factor; bacterial toxin; binding assay
Sperm CD52 GPI anchor and its derivatives containing different carbohydrate chains were prepared, in a highly convergent fashion starting from the same properly protected phospholipidated pseudodisaccharide. Coupling this common key intermediate to various oligosaccharyl donors quickly afforded the framework of the synthetic targets, which was followed by global deprotection to furnish the desired structures. Preliminary studies on the biological properties of the synthetic GPI derivatives indicated that both the intact GPI anchor and the free phospholipidated pseudodisaccharide interacted strongly with CAMP factor, a pore-forming bacterial toxin. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据