期刊
CARBOHYDRATE RESEARCH
卷 343, 期 17, 页码 2894-2902出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.08.024
关键词
CD52; Peptide; Glycopeptide; N-Glycosylation; Circular dichroism (CD); Solid phase synthesis
资金
- NSF [CHE-0407144, 0715275]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0715275] Funding Source: National Science Foundation
The syntheses of five natural and N-terminal acetylated peptides and glycopeptides of the CD52 antigen are described. Solid phase peptide synthesis was employed in the construction of the target compounds from Fmoc-protected commercial amino acids and synthetic glycan-asparagine conjugates. Circular dichroism studies of the synthetic targets showed that they exist as random coils in solution, and no significant change in secondary structure was observed when the CD52 peptide was either acetylated at the N-terminus or glycosylated at the Asn(3) residue with a disaccharide or a fucose-containing branched trisaccharide. (C) 2008 Elsevier Ltd. All rights reserved,
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据