期刊
CARBOHYDRATE RESEARCH
卷 343, 期 17, 页码 2853-2862出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.06.011
关键词
Heparan sulfate; Synthesis; Heparanase; Glycosylation; Thioglycoside; Trifluoroacetimidate
资金
- National Natural Science Foundation of China [20572122, 20621062]
- Committee of Science and Technology of Shanghai [04DZ19213, 06XD14026]
A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely beta-D-GIcA(2S)-(1 -> 4)-alpha-D-GIcN(NS,6S)-(1 -> 4)-beta-D-GIcA-(1 -> 4)-alpha-D-GIcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step. (C) 2008 Elsevier Ltd. All rights reserved.
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