期刊
CARBOHYDRATE POLYMERS
卷 199, 期 -, 页码 649-660出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.07.018
关键词
beta-Cyclodextrin; alpha(1 -> 2) Mannobioside; Homodimerization; Concanavalin A; Nitric oxide
资金
- Spanish Ministry of Economy and Competitiveness [CTQ2013-48380-R, CTQ2017-90050-R]
- European Union through FP7-PEOPLE-2013-ITN project [608407]
Two beta-cyclodextrin derivatives randomly appended on the primary face with both the nitric oxide (NO) photodonor 4-nitro-3-(trifluoromethyl) aniline and a mannose or alpha(1 -> 2) mannobioside residue are reported to construct targeted NO photoreleasing nanocarriers. 2D ROESY and PGSE NMR suggested supramolecular homodimerization in water by inclusion of the nitroaniline group into the facing macrocycle cavities. Isothermal titration calorimetry on their concanavalin A lectin binding showed an exothermic binding event to the lectin and an endothermic process during the dilution of the conjugates. Both alpha(1 -> 2) mannobioside and the nitroaniline moieties significantly enhanced the binding to the lectin. These effects might arise from a better fit within the carbohydrate-recognition site in the former case and a multivalent effect caused by homodimerization in the latter. Direct detection of NO by amperometric technique shows that both beta-cyclodextrin derivatives release this radical upon excitation with visible light with higher efficiency than the unfunctionalized NO photodonor.
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