期刊
CARBOHYDRATE POLYMERS
卷 200, 期 -, 页码 508-515出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.08.036
关键词
Folic acid (FA); Reductive-responsive; Starch; Microcapsule; Targeted delivery and controlled release; Sonochemical
资金
- Natural Science Foundation of the Science and Technology Department of Jilin Province, PR China [20180101072JC]
- Key Program of the Science and Technology Department of Jilin Province, PR China [20180201082SF]
- scientific research Program of the Education Department of Jilin Province (P. R. China) [JJKH20180119KJ]
In this present study, original, biodegradable, biocompatible, non-immunogenic and non-poisonous folic acid (FA) decorated reductive-responsive starch-based microcapsules (FA-RSMCs) were designed and fabricated via the sonochemical method for targeted delivery and controlled release of hydrophobic drugs. A green hydrophobic fluorescent dye, Coumarin 6 (C6), was encapsulated into the FA-RSMCs as a substitute of hydrophobic drugs. The as-synthesized C6-loaded FA-RSMCs were characterized by DLS, SEM and TEM. The results indicated that the obtained C6-loaded FA-RSMCs had an appropriate size range and could enter into the bloodstream with their splendid stability. Moreover, C6-loaded FA-RSMCs showed a high selectivity to Hela cells, and a brilliant targeted drugs delivery and reductive-responsive release ability for hydrophobic drugs, particularly for hydrophobic anti-cancer drugs.
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