期刊
CARBOHYDRATE POLYMERS
卷 202, 期 -, 页码 581-590出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.08.144
关键词
Ganoderma atrum polysaccharide; Doxorubicin; Cardiotoxicity; Myocardial damage
资金
- National Natural Science Foundation of China [31560460]
- Natural Science Foundation of Jiangxi Province [20171ACB21016, 20151BAB204038]
- Youth Research Fund of State Key Laboratory of Food Science and Technology [SKLF-QN-201509]
The present study aimed to determine the cardioprotective effect of Ganoderma atrum polysaccharide (PSG-1) in doxorubicin (DOX)-treated mice and its underlying mechanism. Results indicated that PSG-1 treatment significantly alleviated DOX-induced myocardial damage via attenuating apoptosis and maintaining the structure of myocardial mitochondria. Meanwhile, PSG-1-evoked cardioprotection was associated with an increase of manganese superoxide dismutase activity and decrease of caspases activities. Moreover, administration of PSG-1 suppressed DOX-induced mitochondrial disorders, which was evidenced by reducing reactive oxygen species, elevating mitochondrial membrane potential and inhibiting the opening of mitochondrial permeability transition pore. PSG-1 was also found to reduce the release of cytochrome c from mitochondria to cytoplasm in mice subjected to DOX. Finally, our findings have provided comprehensive evidence for the cardioprotective effects of PSG-1 via reduction of apoptosis mediated by modification of the mitochondrial intrinsic apoptotic pathway, indicating that PSG-1 could be developed as an effective therapeutic strategy to prevent DOX-induced cardiotoxicity in clinical settings.
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