期刊
CARBOHYDRATE POLYMERS
卷 103, 期 -, 页码 502-509出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.12.061
关键词
Chang liver cells; 4-Hydroxybenzyl-chitooligomers (HB-COS); Free radical scavenging; Antioxidant enzymes; Nuclear factor kappa B (NF-kappa B)
资金
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [106.05-2011.36]
In this study, a bioactive derivative of chitooligomers (1.0-3.0 kDa), 4-hydroxybenzyl-COS (HB-COS), was synthesized to enhance antioxidant activity. Hence, HB-COS was evaluated for its capabilities against H2O2-induced oxidative stress in human Chang liver cells. It was found that HB-COS possessed the free radical scavenging activity via decreasing the intracellular reactive oxygen species production. Furthermore, HB-COS significantly reduced the oxidation of DNA in a dose-dependent manner. Notably, HB-COS treatment upregulated the gene and protein expressions of antioxidative enzymes and thereby enhancing the intracellular antioxidant mechanisms. In addition, HB-COS treatment caused a remarkable blockade on degradation of inhibitory kappa B alpha (I kappa B-alpha) protein and translocation of nuclear factor kappa B (NF-kappa B). The current study demonstrated that HB-COS effectively attenuated hydrogen peroxide-induced oxidative stress in Chang liver cells by increasing levels of antioxidant enzymes and inhibiting reactive oxygen species generation, DNA oxidation and the NF-kappa B signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
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