期刊
CARBOHYDRATE POLYMERS
卷 103, 期 -, 页码 466-471出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.12.082
关键词
Chitin nanofiber; Deepeutectic solvents; Ionic liquids; Bio-nanocomposites; Drug slow; Delivery
资金
- Council of Scientific & Industrial Research, New Delhi
- UGC
- CSIR
Deep eutectic solvents (DESs) consisting of the mixtures of choline halide (chloride/bromide)-urea and choline chloride-thiourea were used as solvents to prepare a-chitin nanofibers (CNFs). CNFs of diameter 20-30 nm could be obtained using the DESs comprising of the mixture of choline chloride and thiourea (CCT 1:2); however, NFs could not be obtained using the DESs having urea (CCU 1:2) as hydrogen bond donor. The physicochemical properties of thus obtained NFs were compared with those obtained using a couple of imidazolium based ionic liquids namely, 1-butyl-3-methylimidazolium hydrogen sulphate [(Bmim)HSO4] and 1-methylimidazolium hydrogen sulphate [(Hmim)HSO4] as well as choline based bio-ILs namely, choline hydrogen sulphate [(Chol)HSO4] and choline acrylate. The CNFs obtained using the DES as a solvent were used to prepare calcium alginate bio-nanocomposite gel beads having enhanced elasticity in comparison to Ca-alginate beads. The bio-nanocomposite gel beads thus obtained were used to study slow release of 5-fluorouracil, an anticancer drug. (C) 2014 Elsevier Ltd. All rights reserved.
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