4.7 Article

Controlled release of Lactobacillus rhamnosus biofilm probiotics from alginate-locust bean gum microcapsules

期刊

CARBOHYDRATE POLYMERS
卷 103, 期 -, 页码 587-595

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.01.036

关键词

Functional food; Food microbiology; Nutraceuticals; Gut health; Probiotics capsules

资金

  1. Ministry of Education of Singapore [AcRF RG 76/10]

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Chitosan-coated alginate microcapsules containing high-density biofilm Lactobacillus rhamnosus have been previously shown to exhibit higher freeze drying- and thermal-tolerance than their planktonic counterparts. However, their cell release profile remains poor due to the capsules' susceptibility to the gastric environment. Herein the effects of adding locust bean (LB) and xanthan (XT) gums to alginate (AGN) capsules on the stress tolerance and cell release profiles in simulated gastrointestinal fluids are investigated. Compared to the AGN-only capsules, the AGN-LB capsules exhibit improved stress tolerance (i.e. approximate to 6x for freeze drying, 100x for thermotolerance, 10x for acid), whereas the AGN-XT capsules only improve the acid tolerance. Importantly, the AGN-LB capsules possess the optimal cell release profile with a majority of cells released in the simulated intestinal juice than in the gastric juice. The AGN-LB capsules' superiority is attributed to their stronger interaction with the chitosan coating and high swelling capacity, thus delaying their bulk dissolution. (C) 2014 Elsevier Ltd. All rights reserved.

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