期刊
CARBOHYDRATE POLYMERS
卷 110, 期 -, 页码 173-182出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.03.097
关键词
Chitosan nanoparticles; Cyclodextrins; Ciprofloxacin; Orthopaedic infections; Cytocompatibility; Gene expression
资金
- Universita degli Studi di Bari Aldo Moro (FAR)
- FIRB [RBAP10MLK7]
- PRIN (Universita Politecnica delle Marche) [2010J8RYS7]
A novel ciprofloxacin loaded chitosan nanoparticle-based coating onto titanium substrates has been developed and characterized to obtain an orthopaedic implant surface able to in situ release the antibiotic for the prevention of post-operative infections. Ciprofloxacin loaded chitosan nanoparticles were obtained using the combination of sulfobutyl ether-beta-cyclodextrin and gamma-cyclodextrin. The resulting nanoparticulate system was characterized by TEM, HPLC and XPS. Particle size was in the range 426-552 nm and zeta potential values were around +30 mV. This antibacterial coating was able to in vitro inhibit two nosocomial Staphylococcus aureus strains growth, with a reduction of about 20 times compared to controls. No impairment in MG63 osteoblast-like cells viability, adhesion and gene expression were detected at 48 h, 7 and 14 days of culture. Overall, the investigated coating represents a promising candidate for the development of a new antibiotic carrier for titanium implants. (C) 2014 Elsevier Ltd. All rights reserved.
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