期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 40, 期 5, 页码 269-283出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10409230500315352
关键词
UPR; ATF6; ATF4; PERK; Ire1; XBP-1; ERAD
Homeostasis of the protein folding machinery in the endoplasmic reticulum (ER) is maintained via several parallel unfolded protein response pathways that are remarkably conserved from yeast to man. Together, these pathways are integrated into a complex circuitry that can be modulated in various ways, not only to cope with various stress conditions, but also to fine-tune the capacity of the ER folding machinery when precursor cells differentiate into professional secretory cells.
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