期刊
CARBOHYDRATE POLYMERS
卷 112, 期 -, 页码 1-5出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.05.061
关键词
Wheat bran arabinoxylans; Oat beta-glucan; Hypercholesterolemia; Fecal lipids; Short-chain fatty acids; Hamsters
资金
- International Science & Technology Cooperation Program of China [2012DFA31400]
- National Natural Science Foundation of China [31271852]
The aim of the present study is to investigate the effects of dietary wheat bran arabinoxylans (AXs) on cholesterol metabolism in hypercholesterolemic hamsters. The hamsters were divided into 3 groups and fed the experimental diets containing AXs or oat beta-glucan at a dose of 5 g/kg for 30 days. As the results, the AXs lowered plasma total cholesterol and LDL-cholesterol concentrations, and increased excretions of total lipids, cholesterol and bile acids, as well as oat beta-glucan. The AXs reduced the activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase, and increased the activity of cholesterol 7-alpha hydroxylase (CYP7A1) in liver. Moreover, the AXs increased propionate and the total short-chain fatty acids (SCFAs) concentrations. These results indicated that dietary AXs reduced the plasma total cholesterol and LDL-cholesterol concentrations by promoting the excretion of fecal lipids, regulating the activities of HMG-CoA reductase and CYP7A1, and increasing colonic SCFAs in hamsters. (C) 2014 Elsevier Ltd. All rights reserved.
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