期刊
CARBOHYDRATE POLYMERS
卷 100, 期 -, 页码 166-178出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.12.043
关键词
Silver nanoparticles; Chitosan; Electrospinning; Antimicrobial; Polyvinyl alcohol
Novel hybrid nanomaterials have been developed for antimicrobial applications. Here we introduce a green route to produce antibacterial nanofiber mats loaded with silver nanoparticles (Ag-NPs, 25 nm diameter) enveloped in chitosan after reduction with glucose. The nanofiber mats were obtained from colloidal dispersions of chitosan-based Ag-NPs blended with polyvinyl alcohol. Nanofibers (150 nm average diameter and narrow size distribution) were obtained by electrospinning and cross-linked with glutaraldhyde. The effect of crosslinking on the release of silver was studied by atomic absorption spectroscopy. Antimicrobial activity was studied by the viable cell-counting; mats loaded with silver and control samples (chitosan/PVA) with different degrees of cross-linking were compared for their effectiveness in reducing or halting the growth of aerobic bacteria. The results showed superior properties and synergistic antibacterial effects by combining chitosan with Ag-NPs. (C) 2013 Elsevier Ltd. All rights reserved.
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