期刊
CARBOHYDRATE POLYMERS
卷 99, 期 -, 页码 720-727出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.09.013
关键词
Biotin-modified cholesteryl pullulan; Self-aggregated nanoparticle; Mitoxantrone; Drug delivery
资金
- Natural Science Foundation of Hebei Province [H2012201069]
- Natural Science Foundation of Hebei University, China [2010-193]
A series of biotin modified cholesteryl pullulan (Bio-CHSP) conjugates with different degrees of substitution (DS) of biotin moiety were synthesized and characterized by Fourier transform infrared (FT-IR), proton nuclear magnetic resonance (H-1 NMR) and X-ray diffraction (XRD). Bio-CHSP conjugates were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique. Bio-CHSP self-aggregated nanoparticles (Bio-CHSP NPs) were prepared and analyzed by dynamic light scattering (DLS), zeta potential and transmission electron microscopy (TEM) technologies. These novel nanoparticles were almost spherical in shape, and their size, ranging from 178.8 to 100.0 nm. The safety of Bio-CHSP NPs was studied through single dose toxicity test in mice, and the result showed that Bio-CHSP NPs were well tolerated at the intravenous dose of 200 mg/kg in mice. Moreover, as a model anticancer drug, mitoxantrone loaded Bio-CHSP NPs were also prepared and characterized in this study. (C) 2013 Elsevier Ltd. All rights reserved.
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