期刊
CARBOHYDRATE POLYMERS
卷 113, 期 -, 页码 286-295出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.07.021
关键词
Beads; Gellan gum; Pectin; Ionotropic gelation; Controlled release; Ketoprofen
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Gellan gum/pectin beads were prepared by ionotropic gelation, using Al3+ as crosslinker. High yield (92.76%) and entrapment efficiency (52.22-88.78%) were reached. Beads exhibited high circularity (0.730-0.849) and size between 728.95 and 924.56 m. Particle size and circularity was increased by raising polymer and crosslinker concentrations. Polymers ratio did not influence beads properties. The materials stability and the absence of drug-polymers interactions were evidenced by thermal analysis and FM The high beads mucoadhesiveness was evidenced by in vitro and ex vivo tests. The erosion of beads was greater in acid media while swelling was more pronounced in pH 7.4. Drug release was dependent on pH in which samples 11H1-3, 11H1-5 and 41H1-3 released only 34%, 20% and 22% of ketoprofen in pH 1.2, while in pH 7.4 the drug release was sustained up to 360 min. Korsmeyer-Peppas model demonstrated that drug release occurred according to super case-II transport. (C) 2014 Elsevier Ltd. All rights reserved.
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