期刊
CARBOHYDRATE POLYMERS
卷 99, 期 -, 页码 116-125出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.08.008
关键词
Myricetin; beta-CD; Steady-state and time-resolved fluorescence spectroscopy; Induced circular dichroism; Dual emission; Antioxidant potency; Quantum chemical calculations
Myricetin, a bioactive plant flavonol, readily forms inclusion complex with the drug delivery vehicle beta-cyclodextrin (beta-CD). Appearance of typical dual emission, consisting of normal (470 nm) and ESIPT tautomer (530 nm) bands, with concomitant rise in fluorescence intensity and dramatically blue shifted normal fluorescence of myricetin with increasing beta-CD concentration, indicates facile entry of myricetin into the cavity of beta-CD. The stoichiometry of the inclusion complex has been established to be equimolar (1:1), with an equilibrium constant of 439 +/- 18 M-1 at 25 degrees C. The driving force of inclusion is attributed to strong van der Waals interaction and formation of hydrogen bond between host (beta-CD) and guest (myricetin). Both experimental and theoretical studies indicate that myricetin possibly incorporates within beta-CD through its benzoyl moiety. Inclusion in beta-CD increases the antioxidant potency of myricetin which has been attributed to the less delocalised HOMO and reduced HOMO-LUMO energy gap in the confined state. (C) 2013 Elsevier Ltd. All rights reserved.
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