期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 40, 期 1, 页码 21-73出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230590918612
关键词
C. elegans; Drosophila; oocyte; RNA localization; translational control; Xenopus
资金
- Biotechnology and Biological Sciences Research Council [BB/C514766/1] Funding Source: Medline
RNA-binding proteins play a major part in the control of gene expression during early development. At this stage, the majority of regulation occurs at the levels of translation and RNA localization. These processes are, in general, mediated by RNA-binding proteins interacting with specific sequence motifs in the 3'-untranslated regions of their target RNAs. Although initial work concentrated on the analysis of these sequences and their trans-acting factors, we are now beginning to gain an understanding of the mechanisms by which some of these proteins function. In this review, we will describe a number of different families of RNA-binding proteins, grouping them together on the basis of common regulatory strategies, and emphasizing the recurrent themes that occur, both across different species and as a response to different biological problems.
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