期刊
JOURNAL OF LIPOSOME RESEARCH
卷 15, 期 3-4, 页码 167-174出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08982100500364172
关键词
dimethacrylates; DPPC liposomes; interaction; NMR chemical shifts; DSC; PM3
In the light of recent developments, changes in H-1 and C-13 NMR chemical shifts of methacrylate molecule associated with DMPC (L-alpha dimyristoylphosphatidylcholine) or DPPC (L-alpha-dipalmitoylphosphatidylcholine) liposomes as a model for mimic native lipid bilayers were studied at 30, 37. and 52 degrees C. The chemical shifts of 3Ha, 3C and 4C resonances in methacrylates (see Fig. 2) were greatly shifted higherfield, suggesting the methacrylate molecule-lipid bilayer interaction. Comparison of the findings with methyl methacrylate (MMA), ethylene dimethacrylate (EDMA), and triethyleneglycol dimethacrylate (TEGDMA) revealed that the interaction of dimethacrylates (EDMA, TEGDMA) was greater than monomethacrylate, MMA. Their interaction with DMPC liposomes was also judged by a differential scanning calorimetry (DSC), indicating that the interaction was charcterized by decreasing the enthalpy, entropy, and transition cooerativity. The evidence of the upfield NMR-shifts for methacrylate molecules was also judged by the descriptors such as the reactivity (HOMO-LUMO energy) and the electrostatic function (partial charges) between methacrylate molecules and DPPC calculated by, a PM 3 semiempirical MO method. The upfield NMR shifts were considerably well interpreted from the descriptors. NMR screening technique in methacrylates to phospholipid targets would be highly valuable in biomaterial developments.
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