期刊
ANNUAL REVIEW OF GENETICS
卷 39, 期 -, 页码 47-68出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.39.073003.093745
关键词
trp operon regulation; attenuation; tryptophan sensing; tRNA(Trp) sensing; TRAP regulatory protein; AT regulatory protein
资金
- NIGMS NIH HHS [R01 GM052840] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM052840] Funding Source: NIH RePORTER
Bacillus subtilis uses novel regulatory mechanisms in controlling expression of its genes of tryptophan synthesis and transport. These mechanisms respond to changes in the intracellular concentrations of free tryptophan and uncharged tRNA(Trp). The major B. subtilis protein that regulates tryptophan biosynthesis is the tryptophan-activated RNA-binding attenuation protein TRAP TRAP is a ring- shaped molecule composed of 11 identical subunits. Active TRAP binds to unique RNA segments containing multiple trinucleotide (NAG) repeats. Binding regulates both transcription termination and translation in the trp operon, and translation of other coding regions relevant to tryptophan metabolism. When there is a deficiency of charged tRNA(Trp), B. subtilis forms an anti-TRAP protein, AT. AT antagonizes TRAP function, thereby increasing expression of all the genes regulated by TRAP. Thus B. subtilis and Escherochia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp), yet they employ different mechanisms in regulating trp gene expression.
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