期刊
CARBOHYDRATE POLYMERS
卷 92, 期 1, 页码 621-628出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.09.014
关键词
Chitosan; PNIPAAm; Comb-shape; pH/temperature multi-responsive; ATRP
资金
- Ministry of Education of China [20090211110004]
- Fund for Train Men for Profession of National Natural Science Foundation of China [J1103307]
Comb-shaped copolymers comprised of hydrophobic and hydrophilic blocks are self-assembled in aqueous solution, which results that they are suitable for delivery of hydrophobic drug molecules. Chitosan (CS) is an important biomaterial used widely in medical applications. Herein, a comb-shaped cationic copolymer composed of long biocompatible CS main chains and short PNIPAAm side chains was prepared via atom transfer radical polymerization (ATRP) by attaching an ATRP initiating group to N-phthaloyl chitosan. By subsequent removal of the protective groups on N-phthaloyl chitosan-graft-poly(N-isopropylacrylamide) (PHCS-g-PNIPAAm) copolymer with N2H4 center dot H2O lead to the polymer pendant amino groups, this study attempted to synthesize a pH/temperature multi-responsive material. This chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymer is self-assembled in aqueous solution into stimuli-responsive core-shell micelles with hydrodynamic diameters of about 170 nm. Structural organization and solution behavior were then investigated utilizing H-1 NMR spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). (C) 2012 Elsevier Ltd. All rights reserved.
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