期刊
CARBOHYDRATE POLYMERS
卷 95, 期 1, 页码 134-142出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.02.067
关键词
Injectable bone substitute; Alginate-based hydrogels; Bone regeneration; Physical-chemical characterization
资金
- FCT (Fundacao para a Ciencia e a Tecnologia) [SFRH/BD/76237/2011, ENMED/0002/2010]
- FEDER funds through the program COMPETE - Programa Operacional Factores de Competitividade [PEstC/EME/UI0285/2011, 1372]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/76237/2011, ENMED/0002/2010] Funding Source: FCT
In this work three different hydrogels were developed to associate, as vehicles, with the synthetic bone substitute GR-HAP. One based on an alginate matrix (Alg); a second on a mixture of alginate and chitosan (Alg/Ch); and a third on alginate and hyaluronate (Alg/HA), using Ca2+ ions as cross-linking agents. The hydrogels, as well as the respective injectable bone substitutes (IBSs), were fully characterized from the physical-chemical point of view. Weight change studies proved that all hydrogels were able to swell and degrade within 72 h at pH 7.4 and 4.0, being Alg/HA the hydrogel with the highest degradation rate (80%). Rheology studies demonstrated that all hydrogels are non-Newtonian viscoelastic fluids, and injectability tests showed that IBSs presented low maximum extrusion forces, as well as quite stable average forces. In conclusion, the studied hydrogels present the necessary features to be successfully used as vehicles of GR-HAP, particularly the hydrogel Alg/HA. (C) 2013 Elsevier Ltd. All rights reserved.
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