期刊
CARBOHYDRATE POLYMERS
卷 94, 期 1, 页码 56-62出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.01.006
关键词
Characterization; Hyperlipidemia; Peroxisome proliferator-activated receptor; Lipoprotein lipase
资金
- Zhejiang Provincial Natural Science Foundation of China [Y3110366]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia. (C) 2013 Elsevier Ltd. All rights reserved.
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