期刊
CARBOHYDRATE POLYMERS
卷 98, 期 1, 页码 1173-1178出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.07.021
关键词
Chitosan; Nanoparticles; PAMAM; Drug delivery; Methotrexate
资金
- National Natural Science Foundation of China [91227122, 21063004]
Encapsulating anticancer drugs to synthetic polymer is a promising approach to improve the efficiency and reduce the side effects of anticancer drugs. In this study, novel chitosan derivatives with polyamidoamine moieties (CS-PAMAM) were synthesized and characterized by morphology, particle size, and zeta potential. Then the anticancer drug-methotrexate-encapsulated CS-PAMAM was prepared by hydrophobic-hydrophilic interactions. The drug release assay showed that the amount of the methotrexate release from CS-PAMAM was pH depended. Meanwhile, the cell viability assay illustrated that CS-PAMAM was suitable for the drug delivery because of its low cytotoxicity on cells. Moreover, our results showed that the CS-PAMAM could significantly improve the cytotoxicity of free methotrexate on A549 cells. These results demonstrate that CS-PAMAM may provide a suitable platform for the water-insoluble drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.
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