期刊
CARBOHYDRATE POLYMERS
卷 96, 期 2, 页码 426-434出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.04.013
关键词
Anionic starch nanospheres; Soluble starch; Thrombolytic behavior; NK
资金
- Special Doctorial Program Fund of the Ministry of Education of China [20090211110004]
- Fund for Train Men for profession of National Natural Science Foundation of China [J1103307]
This paper is considered as the first report on the investigation of nattokinase (NK) release from anionic starch nanospheres. The ultra-small and anionic starch nanospheres were prepared by the method of reverse micro-emulsion crosslinking in this work. Starch nanospheres were characterized through Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS). Effects of preparation conditions on particle size were studied. The cytotoxicity, biodegradable and vitro thrombolytic behaviors of nattokinase (NK) loaded anionic starch nanospheres were also studied. The results showed that the anionic starch nanospheres are non-toxic, biocompatible and biodegradable. Moreover, the anionic starch nanospheres can protect NK from fast biodegradation hence prolongs the circulation in vivo and can reduce the risk of acute hemorrhage complication by decreasing the thrombolysis rate. (C) 2013 Elsevier Ltd. All rights reserved.
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