期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 30, 期 6, 页码 1027-1033出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2014.1001755
关键词
Anti-leishmanial agents; anti-malarial agents; Crocus sativus L.; Helicobacter pylori; safranal
资金
- Interregional Research Center for Food Safety and Health at the Magna Graecia University of Catanzaro (MIUR) [PON a3_00359]
Crocus sativus L. is known in herbal medicine for the various pharmacological effects of its components, but no data are found in literature about its biological properties toward Helicobacter pylori, Plasmodium spp. and Leishmania spp. In this work, the potential antibacterial and anti-parasitic effects of crocin and safranal, two important bioactive components in C. sativus, were explored, and also some semi-synthetic derivatives of safranal were tested in order to establish which modifications in the chemical structure could improve the biological activity. According to our promising results, we virtually screened our compounds by means of molecular modeling studies against the main H. pylori enzymes in order to unravel their putative mechanism of action.
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