期刊
CARBOHYDRATE POLYMERS
卷 97, 期 2, 页码 469-474出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.05.009
关键词
Nickel nanoparticles; Chitin nanogels; Cytocompatibility; Antibacterial activity; Biomedical applications
资金
- Department of Biotechnology (DBT), Government of India of the Nanoscience and Nanotechnology Initiative program [BT/PR10850/NNT/28/127/2008]
- Council of Scientific and Industrial Research (CSIR) [9/963 (0017)2K11-EMR]
In this work, we developed 120-150 nm sized nickel nanoparticles loaded chitin nanogels (Ni-Chitin NGs) by regeneration chemistry approach to investigate and determine its cytocompatibility and antibacterial activity against Staphylococcus aureus. The nickel nanoparticles were prepared by hydrothermal method. The prepared Ni-Chitin NGs were well characterized by SEM, FTIR, TG/DTA/DTG and XRD and the in vitro cytocompatibility was tested on A549 and L929 cells which showed that they are completely non-toxic. Ni-Chitin NGs showed better toxicity to the bacterial strains when compared to previous study with other nanoparticles using serial dilution method. The rhodamine labeled-Ni-Chitin NGs showed cellular localization on both L929 and A549 cells without perturbing their cellular constituents. These studies showed that the Ni-Chitin NGs could be used for various applications in biomedical filed. (C) 2013 Elsevier Ltd. All rights reserved.
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