期刊
CARBOHYDRATE POLYMERS
卷 90, 期 4, 页码 1445-1451出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.07.013
关键词
Core-shell structure; Electrospinning; Poly(lactic acid); Homogeneous solution; Chitosan
资金
- National Natural Science Foundation of China [50803004]
- Beijing Natural Science Foundation [2112033]
- Fundamental Research Funds for the Central Universities [ZZ1115]
The core-shell structure nanofibers of poly(lactic acid)/chitosan with different weight ratios were successfully electrospun from homogeneous solution. The preparation process was more simple and effective than double-needle electrospinning. The nanofibers were obtained with chitosan in shell while poly(lactic acid) in core attributing to phase separation, which were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM). X-ray diffraction (XRD) and energy dispersive spectrometer (EDS). The electrospun nanofibrous membrane was evaluated in vitro by using mouse fibroblasts (L929) as reference cell lines. Cell culture results indicated that these materials were good in promoting cell growth and attachment, thus they could be used for tissue engineering and wound healing dressing. (C) 2012 Elsevier Ltd. All rights reserved.
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