期刊
CARBOHYDRATE POLYMERS
卷 89, 期 2, 页码 623-631出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.03.060
关键词
beta-Cyclodextrin; Chitosan; Eugenol; Mucoadhesive; Surface plasmon resonance; Mucosal carrier
资金
- Research, Development and Engineering (RD&E) through National Nanotechnology Center (NANOTEC)
- National Science and Technology Development Agency (NSTDA), Thailand [NN-B-22-EN7-94-51-20]
Inclusion complex between water-soluble beta CD-grafted chitosan derivatives (QCD-g-CS) and eugenol (EG) was investigated as a new type of mucoadhesive drug carrier. The QCD-g-CSs were synthesized with various beta CD moieties ranging from 5 to 23%. Spontaneous inclusion complex of these derivatives and EG were found and confirmed by FTIR and simulation study. Self-aggregated formations of QCD-g-CS were found, according to fluorescence and TEM studies, where the formations were preferable for QCD11g-CS and QCD5-g-CS. EG can be included in both beta CD hydrophobic cavity and hydrophobic core of QCD-g-CS self-aggregates, resulting in varying entrapment efficiencies. Degree of QCD substitution on QCD-g-CS plays an important role on their physical properties, due to steric hindrance. The QCD11-g-CS showed excellent mucoadhesion, compared to the QCD5-g-CS and QCD23-g-CS. Moreover, the inclusion complex between QCD-g-CS and EG tend to express higher antimicrobial activities against Candida albicans, Streptococcus oralis and Streptococcus mutans, than the native QCD-g-CS. (C) 2012 Elsevier Ltd. All rights reserved.
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